Trinity Western University

Faculty Directory

Eve Stringham-Durovic, Ph.D.

Canada Research Chair in Developmental Genetics and Disease, Professor of Biology

  • Education

    B.Sc., University of Manitoba, 1984.
    M.Sc., University of Manitoba, 1987.
    Ph.D., University of British Columbia, 1992.

  • Recent Publications

    Kristopher L. Schmidt, Nancy Marcus-Gueret, Adetayo Adeleye, Jordan Webber, David Baillie, and Eve G. Stringham. (2009) The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1. Development;136 563-574 Open Access http://dev.biologists.org/cgi/content/abstract/136/4/563?etoc.

    Stringham, E.G. Teaching future scientists and physicians to think about cancer treatment, spiritually.  (2002) Selected Proceedings on Searching for Meaning in the New Millennium. INPM Press.

    Stringham, E., Pujol, N., Vandekerckhove, J. and Bogaert, T.(2002) Unc-53 controls longitudinal migration in C. elegans. Development 129:3367-3379.

    Mutwakil, M.H.A.Z, J.P. Reader, D.M. Holdich, P.R. Smithurst, E.P.M. Candido, D. Jones, E.G. Stringham and D.I. de Pomerai. (1997) Use of stress inducible transgenic nematodes as biomarkers of heavy metal pollution in water samples from an English river system. Arch. Env. Contam.Toxicol. 32: 146-153.

    Jones, D., E.G. Stringham, S.L. Babich and E.P.M. Candido. (1996) Captan induces the s tress response and inhibits feeding in a nematode biomonitor. Toxicol. 109: 119-127.

    Jones, D., E.G. Stringham, R.W. Graham and E.P.M. Candido. (1995) A portable regulatory element directs gonad specific expression of the Caenorhabditis elegans ubiquitin gene ubq-2. Develop. Biol. 171: 60-72.

    Stringham, E.G. and E.P.M. Candido. (1994) Transgenic hsp16-lacZ strains of the soil nematode Caenorhabditis elegans as biological monitors of environmental stress. Environ. Toxicol. Chem. 13:1211-1220.

    Stringham, E.G. and E.P.M. Candido. (1993) Induction of the heat shock response in individual cells of C. elegans using a laser microbeam. J. Exp. Zool. 266: 227-233.

    Stringham, E.G., D. Jones and E.P.M. Candido. (1992) Analysis of polyubiquitin gene (ubq-1) expression in transgenic Caenorhabditis elegans. Gene 113: 165-173.

    Stringham, E.G., D.K. Dixon, D. Jones and E.P.M. Candido (1992). Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic C. elegans.Molec. Biol. Cell. 3: 221-233.

     

  • Memberships & Affiliations

    • Members of the Society for Developmental Biologists
    • Adjunct Professor of Molecular Biology and Biochemistry, SFU
  • Courses Taught at TWU

    Cell Biology (BIOL 223)
    Molecular Genetics (BIOL 372)
    Developmental Biology (BIOL 340)
    Neoplasia (BIOL 474)
    Biotechnology and Christian Theology (BIOT 390)
    Senior Thesis supervision (BIOL 409/410)

  • Awards & Honours

    • Canadian Research Chair in Developmental Genetics and Disease
    • NSERC Discovery Grant
    • European Molecular Biology Organization
  • Area of Research

    How does a migrating cell know in which direction to turn? What steers an axon along the correct path during outgrowth? How does a cell or growth cone know when it has reached its final destination? These are the questions my laboratory is interested in. We have chosen the soil nematode Caenorhabditis elegans as a model system because of its powerful genetics and transparency, which allows for individual cells and their processes to be viewed by light microscopy.
    Our starting point has been the study of the unc-53 gene, which is required for the directional guidance and extension of a subset of cells: the mechanosensory neurons, the excretory canals and the sex muscles in the anterior-posterior (longitudinal) axis of the worm. In vitro, UNC-53 protein binds actin and the SH2SH3 adapter protein SEM-5/GRB2, which is a key component of various receptor tyrosine kinase (RTK) signaling pathways. While extension of muscle cells in unc-53 mutants is reduced, overexpression of UNC-53 in muscle cells results in increased extension of these cells during embryogenesis. Together, the biochemical and genetic evidence suggest that UNC-53 may act to interpret or relay a signal from the cell surface to the actin cortex to promote a cytoskeletal rearrangement that favours outgrowth in a particular direction.

    We are utilizing two basic approaches to identify additional molecules that are involved in pathfinding. The first approach utilizes genetic screens to identify mutants with defects in steering and outgrowth of the excretory canals and/or the mechanosensory neurons. The excretory cell is an excellent model growth cone to use in this type of analysis because the cell body is located in the anterior end of the animal and extends two short processes anteriorly and two long canals posteriorly along the length of the animal. This bi-directional and short vs. long trajectory allows us to select for mutations that specifically affect only certain aspects of longitudinal pathfinding. The second approach utilizes protein-protein interactions to identify interacting cell guidance molecules. The combination of these approaches should help to elucidate the molecules and processes which control the guidance of migrating or outgrowing cells.

     

    Of worms and men: what model organisms tell us about human disease. Canada Research Chair in Developmental Genetics and Disease Inaugural Address, November 8, 2007. [Powerpoint]

    The Garden of Faith. Graduation Address to the Faculty of Natural and Applied Sciences, Trinity Western University, April 28, 2007. [PDF]

Faculty of Natural and Applied Sciences

Department or Program:

Biology
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